Synthesis, self-assembly and drug release study of a new dual-responsive biocompatible block copolymer containing phenylalanine derivative

Stimuli-responsive polymers as drug delivery vehicles have generated remarkable interest among polymer researchers during the last decade. In present work, we report synthesis of a new water soluble pH- and thermo-responsive biocompatible block copolymer containing phenylalanine derivatives. The formed micelle-like self-assembled nanoparticles above critical aggregation concentration, confirmed from fluorescence spectroscopy, DLS, AFM studies. self-assembly behavior was dependent on pH temperature aqueous media. These micellar were capable encapsulating hydrophobic drugs demonstrated by significantly higher loading capacity value Doxorubicin (DOX) compared to commonly reported values in literature. release DOX favored at lower temperature, condition prevalent cancer cells. Biocompatibility effectiveness potential therapy established 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) studies using non-cancerous murine fibroblasts L929 cells breast cell line MDA MB 231 37 °C 42 °C. cytotoxicity loaded found be more effective Thus, these hold promise application therapy.